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Friday, July 17, 2020 | History

2 edition of Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity found in the catalog.

Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity

National Cancer Institute (U.S.).

Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity

by National Cancer Institute (U.S.).

  • 118 Want to read
  • 29 Currently reading

Published by Dept. of Health and Human Services, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogenicity testing.,
  • Toluene -- Toxicology.,
  • Polyurethanes.,
  • Elastomers.

  • Edition Notes

    StatementCarcinogenesis Testing Program, National Cancer Institute, National Institutes of Health, and National Toxicology Program.
    SeriesCarcinogenesis technical report series ; no. 200, DHHS publication ; no. (NIH) 80-1756, NTP ; 80-20, DHHS publication -- no. (NIH) 80-1756., NTP (Series) -- 80-20.
    ContributionsNational Institutes of Health (U.S.).
    The Physical Object
    Paginationx, 110 p. :
    Number of Pages110
    ID Numbers
    Open LibraryOL18017696M

    Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity (). Characterization of mutations induced by 2-aminomethylphenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G: C deletions beside runs of identical bases. The estimated pKa of (3) indicates 2,6-diaminotoluene will exist partially in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process. 2,6-Diaminotoluene is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of X mm Hg(4).

    A bioassay for possible carcinogenicity of 2-NpP was conducted using Fischer rats and B6C3F1 mice (Anonymous, b). The highest doses of 2-NpP used for male rats, female rats, and both sexes of mice were ppm, ppm, and ppm, by: Bioassay of 2,6-toluenediamine hydrochloride for possible carcinogenicity. Accessed on: Octo Last Updated: Octo Lewandowski T.A. () Risk Assessment Approaches for Dealing With Unusual Chemicals and Non-Standard Exposures. In: Simeonov L.I., Hassanien M.A. (eds) Exposure and Risk Assessment of Chemical Pollution Author: Thomas A. Lewandowski.

    Search results for 2,6- toluenediamine at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare.   National Toxicology Program. Bioassay of 2,4-diaminotoluene for possible carcinogenicity. Natl. Cancer Inst. Carcinog. Tech. Rep. Ser. ; – [Google Scholar] National Toxicology Program. Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity (CAS No. ) Natl. Toxicol.


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Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity by National Cancer Institute (U.S.). Download PDF EPUB FB2

2,6-Toluenediamine is used as an intermediate in the production of dyes for furs and textiles, and of flexible polyurethane foams and elastomers. A bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity was conducted by feeding diets containing the test chemical to F rats and B6C3F1 mice.

Get this from a library. Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity. [Mason Research Institute.; Carcinogenesis Testing Program (U.S.); National Institutes of Health (U.S.)]. 2,6-Toluenediamine is used as an intermediate in the productio onf dyes for furs an d textiles, an d of flexibl polyurethane e foam ans d elastomers A bioassay of 2,6-toluenediamin dihydrochloride for possible e carcinogenicity.

A bioassay of p-phenylenediamine dihydrochloride for possible. carcinogenicity wa conductes d using Fische 34r4 rats and B6C3F1 mice. p-Phenylenediamin dihydrochloridee was administere idn the. feed, at either of two concentrations t,o groups of 50 male and female animal osf each species Th.

higeh and low concentration s. /LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ A bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity was conducted by feeding diets containing the test chemical to F rats and B6C3F1 mice.

Groups of 50 rats of each sex were fed the test chemical at or ppm, for weeks. Get this from a library. Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.].

occupational exposure limits for 2,6-toluenediamine. IARC () has not classified 2,6-toluenediamine as to possible human carcinogenicity. NCI () conducted a chronic carcinogenicity bioassay of 2,6-toluenediamine in rats and mice, which served as the basis for the RfD values in the HEEP (U.S.

EPA, ) and HEAST (U.S. EPA, ). 2,6-TOLUENEDIAMINE DIHYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than They react as acids to neutralize bases.

2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride): Target Organs and Levels of Evidence for TR Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CASRN ) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels.

Get this from a library. Bioassay of n-(1-naphthyl)ethylenediamine dihydrochloride for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.]. Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CAS No ).

Technical Report Series No. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Bethesda, by: Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CAS No ). Technical Report Series No. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Bethesda, Maryland.

Google ScholarCited by:   2,6-Toluenediamine is used as an intermediate in the production of dyes for furs and textiles, and of flexible polyurethane foams and elastomers. A bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity was conducted by feeding diets containing the test chemical to F rats and B6C3F1 mice.

Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity by National Cancer Institute (U.S.) 2 editions - first published in Not in Library. report on the bioassay of n-(1-naphthyl)ethylenediamine dihydrochloride for possible carcinogenicity.

carcinogenesis testing program division of cancer cause and prevention national cancer institute, national institutes of health. foreword: this report presents the results of the bioassay ofFile Size: 5MB.

National Toxicology Program. Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity (CAS No. ) Natl. Toxicol. Program Tech.

Rep. Ser. ; – Nohmi T. Possible mechanisms of practical thresholds for genotoxicity. Genes Environ. ; –Cited by:   Monocyclic aromatic amino and nitro compounds [MAK Value Documentation, ] toxicity, genotoxicity and carcinogenicity, classification in a carcinogen category Bioassay of 2,6-Diaminotoluene Dihydrochloride for Possible Carcinogenicity, National Cancer Institute, Bethesda, MD () Technical Report Series no.

CAS No. 4Cited by: NTP. TR 2,6-Toluenediamine dihydrochloride (). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Author(s): Mason Research Institute.; Carcinogenesis Testing Program (U.S.); National Institutes of Health (U.S.) Title(s): Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity/ Carcinogenesis Testing Program, National Cancer Institute, National Institutes of Health and National Toxicology Program.

μg of 2,4-toluenediamine and μg of 2,6-toluenediamine in 15 mL of sampling medium. Aliquots (2 mL) were treated with 10 μL of acetic anhydride and allowed to stand to 6 h before further workup and analysis. The acetylation of 2,6-toluenediamine was the slower reaction, but it .Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M.

Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III.National Cancer Institute () Bioassay of 2,6-toluenedia- mine dihydrochloride for possible carcinogenicity, Na- tional Cancer Institute Carcinogenesis Technical Report Series, No.NIH Publication No.NCI, Na- tional Institutes of Health, Bethesda, MD Pienta, R.J., M.J.

Shah, W.B. Lebherz IIl, and A.W. Andrews ( Cited by: